Neoamphimedine Circumvents Metnase-Enhanced DNA Topoisomerase IIα Activity Through ATP-Competitive Inhibition

Type IIα DNA topoisomerase (TopoIIα) is among the most important clinical drug targets for the treatment of cancer. Recently, the DNA repair protein Metnase was shown to enhance TopoIIα activity and increase resistance to TopoIIα poisons. Using in vitro DNA decatenation assays we show that neoamphim...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Ponder, Jessica, Yoo, Byong Hoon, Abraham, Adedoyin D., Li, Qun, Ashley, Amanda K., Amerin, Courtney L., Zhou, Qiong, Reid, Brian G., Reigan, Philip, Hromas, Robert, Nickoloff, Jac A., LaBarbera, Daniel V.
Format: Artigo
Sprog:Inglês
Udgivet: Molecular Diversity Preservation International 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229241/
https://ncbi.nlm.nih.gov/pubmed/22163192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md9112397
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker