Crystal structure-based virtual screening for novel fragment-like ligands of the human histamine H(1) receptor

The recent crystal structure determinations of druggable class A G protein-coupled receptors (GPCRs) has opened up excellent opportunities in structure-based ligand discovery for this pharmaceutically important protein family. We have developed and validated a customized structure-based virtual frag...

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Main Authors: de Graaf, C., Kooistra, A.J., Vischer, H.F., Katritch, V., Kuijer, M., Shiroishi, M., Iwata, S., Shimamura, T., Stevens, R.C., de Esch, I.J.P., Leurs, R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228891/
https://ncbi.nlm.nih.gov/pubmed/22007643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm2011589
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