Central action of dendrotoxin: selective reduction of a transient K conductance in hippocampus and binding to localized acceptors.
Dendrotoxin, a small single-chain protein from the venom of Dendroaspis angusticeps, is highly toxic following intracerebroventricular injection into rats. Voltage-clamp analysis of CA1 neurons in hippocampal slices, treated with tetrodotoxin, revealed that nanomolar concentrations of dendrotoxin re...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1986
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC322886/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2417246/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.2.493 |
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