The Tumor Inhibitor and Antiangiogenic Agent Withaferin A Targets the Intermediate Filament Protein Vimentin

The natural product withaferin A (WFA) exhibits antitumor and antiangiogenesis activity in vivo, which results from this drug’s potent growth inhibitory activities. Here, we show that WFA binds to the intermediate filament (IF) protein, vimentin, by covalently modifying its cysteine residue, which i...

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Autors principals: Bargagna-Mohan, Paola, Hamza, Adel, Kim, Yang-eon, Ho, Yik Khuan (Abby), Mor-Vaknin, Nirit, Wendschlag, Nicole, Liu, Junjun, Evans, Robert M., Markovitz, David M., Zhan, Chang-Guo, Kim, Kyung Bo, Mohan, Royce
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228641/
https://ncbi.nlm.nih.gov/pubmed/17584610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.04.010
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