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Development of withaferin A analogs as probes of angiogenesis
The natural product withaferin A (WFA) is a potent angiogenesis inhibitor and it targets the ubiquitin–proteasome pathway in vascular endothelial cells. We generated a biotinylated affinity analog WFA-LC(2)B for use as a probe to study angiogenesis. WFA-LC(2)B inhibits angiogenic sprouting in vitro...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2006
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3222585/ https://ncbi.nlm.nih.gov/pubmed/16513346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2006.02.039 |
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