The Tumor Inhibitor and Antiangiogenic Agent Withaferin A Targets the Intermediate Filament Protein Vimentin

The natural product withaferin A (WFA) exhibits antitumor and antiangiogenesis activity in vivo, which results from this drug’s potent growth inhibitory activities. Here, we show that WFA binds to the intermediate filament (IF) protein, vimentin, by covalently modifying its cysteine residue, which i...

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Detalhes bibliográficos
Main Authors: Bargagna-Mohan, Paola, Hamza, Adel, Kim, Yang-eon, Ho, Yik Khuan (Abby), Mor-Vaknin, Nirit, Wendschlag, Nicole, Liu, Junjun, Evans, Robert M., Markovitz, David M., Zhan, Chang-Guo, Kim, Kyung Bo, Mohan, Royce
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228641/
https://ncbi.nlm.nih.gov/pubmed/17584610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2007.04.010
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