LFA-1 blockade induces effector and regulatory T-cell enrichment in lymph nodes and synergizes with CTLA-4Ig to inhibit effector function

Despite encouraging results using lymphocyte function antigen-1 (LFA-1) blockade to inhibit BM and solid organ transplantation rejection in nonhuman primates and humans, the precise mechanisms underlying its therapeutic potential are still poorly understood. Using a fully allogeneic murine transplan...

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Détails bibliographiques
Auteurs principaux: Reisman, Natalie M., Floyd, Tamara L., Wagener, Maylene E., Kirk, Allan D., Larsen, Christian P., Ford, Mandy L.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2011
Sujets:
Immunobiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228500/
https://ncbi.nlm.nih.gov/pubmed/21972294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-347252
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