High Frequency Alloreactive T Cells Augment Effector Function of Low Frequency CD8(+) T Cell Responses Under CD28/CD154 Blockade

BACKGROUND: Blockade of costimulatory molecules is a potent method of inducing long-term graft survival. We have previously addressed the issue of donor-reactive T cell precursor frequency on relative costimulation dependence, and found that the presence of a high precursor frequency of donor-reacti...

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Main Authors: Floyd, Tamara L., Orr, Steven B., Coley, Shana M., Hanna, Samantha S., Wagener, Maylene E., Kirk, Allan D., Larsen, Christian P., Ford, Mandy L.
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935314/
https://ncbi.nlm.nih.gov/pubmed/20407401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e3181df53dc
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