Astrocytes in aged non-human primate brain gray matter synthesize excess hyaluronan

The glycosaminoglycan hyaluronan (HA) accumulates in central nervous system lesions where it limits astrogliosis but also inhibits oligodendrocyte progenitor cell (OPC) maturation. The role of hyaluronan in normative brain aging has not been previously investigated. Here, we tested the hypothesis th...

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Autori principali: Cargill, Robert, Kohama, Steven G., Struve, Jaime, Su, Weiping, Banine, Fatima, Witkowski, Ellen, Back, Stephen A., Sherman, Larry S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227765/
https://ncbi.nlm.nih.gov/pubmed/21872361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2011.07.006
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