Astrocytes in aged non-human primate brain gray matter synthesize excess hyaluronan

The glycosaminoglycan hyaluronan (HA) accumulates in central nervous system lesions where it limits astrogliosis but also inhibits oligodendrocyte progenitor cell (OPC) maturation. The role of hyaluronan in normative brain aging has not been previously investigated. Here, we tested the hypothesis th...

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Bibliographic Details
Main Authors: Cargill, Robert, Kohama, Steven G., Struve, Jaime, Su, Weiping, Banine, Fatima, Witkowski, Ellen, Back, Stephen A., Sherman, Larry S.
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227765/
https://ncbi.nlm.nih.gov/pubmed/21872361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2011.07.006
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