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Astrocytes in aged non-human primate brain gray matter synthesize excess hyaluronan

The glycosaminoglycan hyaluronan (HA) accumulates in central nervous system lesions where it limits astrogliosis but also inhibits oligodendrocyte progenitor cell (OPC) maturation. The role of hyaluronan in normative brain aging has not been previously investigated. Here, we tested the hypothesis th...

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Autors principals: Cargill, Robert, Kohama, Steven G., Struve, Jaime, Su, Weiping, Banine, Fatima, Witkowski, Ellen, Back, Stephen A., Sherman, Larry S.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227765/
https://ncbi.nlm.nih.gov/pubmed/21872361
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2011.07.006
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