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On the Evolutionary Origin of Eukaryotic DNA Methyltransferases and Dnmt2

The Dnmt2 enzymes show strong amino acid sequence similarity with eukaryotic and prokaryotic DNA-(cytosine C5)-methyltransferases. Yet, Dnmt2 enzymes from several species were shown to methylate tRNA-Asp and had been proposed that eukaryotic DNA methyltransferases evolved from a Dnmt2-like tRNA meth...

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Détails bibliographiques
Auteurs principaux: Jurkowski, Tomasz P., Jeltsch, Albert
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227630/
https://ncbi.nlm.nih.gov/pubmed/22140515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028104
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