Structure-based development of novel sirtuin inhibitors

Sirtuins are NAD(+)-dependent protein deacetylases regulating metabolism, stress responses, and aging processes. Mammalia possess seven Sirtuin isoforms, Sirt1-7, which differ in their subcellular localization and in the substrate proteins they deacetylate. The physiological roles of Sirtuins and th...

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Autores principales: Schlicker, Christine, Boanca, Gina, Lakshminarasimhan, Mahadevan, Steegborn, Clemens
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2011
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227451/
https://ncbi.nlm.nih.gov/pubmed/21937767
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