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A Nine Amino Acid Domain Is Essential for Mutant Prion Protein Toxicity
Transgenic mice expressing prion protein (PrP) molecules with several different internal deletions display spontaneous neurodegenerative phenotypes that can be dose-dependently suppressed by coexpression of wild-type PrP. Each of these deletions, including the largest one (Δ32–134), retains 9 aa imm...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Society for Neuroscience
2011
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3227396/ https://ncbi.nlm.nih.gov/pubmed/21957261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1243-11.2011 |
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