Small-molecule MAPK inhibitors restore radioiodine incorporation in mouse thyroid cancers with conditional BRAF activation

Advanced human thyroid cancers, particularly those that are refractory to treatment with radioiodine (RAI), have a high prevalence of BRAF (v-raf murine sarcoma viral oncogene homolog B1) mutations. However, the degree to which these cancers are dependent on BRAF expression is still unclear. To addr...

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Detalhes bibliográficos
Main Authors: Chakravarty, Debyani, Santos, Elmer, Ryder, Mabel, Knauf, Jeffrey A., Liao, Xiao-Hui, West, Brian L., Bollag, Gideon, Kolesnick, Richard, Thin, Tin Htwe, Rosen, Neal, Zanzonico, Pat, Larson, Steven M., Refetoff, Samuel, Ghossein, Ronald, Fagin, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225989/
https://ncbi.nlm.nih.gov/pubmed/22105174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46382
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