Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice

Mutations of BRAF are found in ∼45% of papillary thyroid cancers and are enriched in tumors with more aggressive properties. We developed mice with a thyroid-specific knock-in of oncogenic Braf (LSL-Braf(V600E)/TPO-Cre) to explore the role of endogenous expression of this oncoprotein on tumor initia...

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Dettagli Bibliografici
Autori principali: Franco, Aime T., Malaguarnera, Roberta, Refetoff, Samuel, Liao, Xiao-Hui, Lundsmith, Emma, Kimura, Shioko, Pritchard, Catrin, Marais, Richard, Davies, Terry F., Weinstein, Lee S., Chen, Min, Rosen, Neal, Ghossein, Ronald, Knauf, Jeffrey A., Fagin, James A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3029699/
https://ncbi.nlm.nih.gov/pubmed/21220306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015557108
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