Genetic and Pharmacological Targeting of CSF-1/CSF-1R Inhibits Tumor-Associated Macrophages and Impairs BRAF-Induced Thyroid Cancer Progression

Advanced human thyroid cancers are densely infiltrated with tumor-associated macrophages (TAMs) and this correlates with a poor prognosis. We used BRAF-induced papillary thyroid cancer (PTC) mouse models to examine the role of TAMs in PTC progression. Following conditional activation of BRAF(V600E)...

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Detalhes bibliográficos
Main Authors: Ryder, Mabel, Gild, Matti, Hohl, Tobias M., Pamer, Eric, Knauf, Jeff, Ghossein, Ronald, Joyce, Johanna A., Fagin, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3553126/
https://ncbi.nlm.nih.gov/pubmed/23372702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054302
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