Impact of Pre-Existing Immunity on Gene Transfer to Nonhuman Primate Liver with Adeno-Associated Virus 8 Vectors

Vectors based on the primate-derived adeno-associated virus serotype 8 (AAV8) are being evaluated in preclinical and clinical models. Natural infections with related AAVs activate memory B cells that produce antibodies capable of modulating the efficacy and safety of the vector. We have evaluated th...

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Detalhes bibliográficos
Main Authors: Wang, Lili, Calcedo, Roberto, Bell, Peter, Lin, Jianping, Grant, Rebecca L, Siegel, Don L, Wilson, James M.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2011
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225046/
https://ncbi.nlm.nih.gov/pubmed/21476868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2011.031
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