Phosphodiesterase 4B in the cardiac L-type Ca(2+) channel complex regulates Ca(2+) current and protects against ventricular arrhythmias in mice

β-Adrenergic receptors (β-ARs) enhance cardiac contractility by increasing cAMP levels and activating PKA. PKA increases Ca(2+)-induced Ca(2+) release via phosphorylation of L-type Ca(2+) channels (LTCCs) and ryanodine receptor 2. Multiple cyclic nucleotide phosphodiesterases (PDEs) regulate local c...

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Detalhes bibliográficos
Main Authors: Leroy, Jérôme, Richter, Wito, Mika, Delphine, Castro, Liliana R.V., Abi-Gerges, Aniella, Xie, Moses, Scheitrum, Colleen, Lefebvre, Florence, Schittl, Julia, Mateo, Philippe, Westenbroek, Ruth, Catterall, William A., Charpentier, Flavien, Conti, Marco, Fischmeister, Rodolphe, Vandecasteele, Grégoire
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223827/
https://ncbi.nlm.nih.gov/pubmed/21670503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI44747
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