The Jak2 Inhibitor, G6, Alleviates Jak2-V617F-Mediated Myeloproliferative Neoplasia by Providing Significant Therapeutic Efficacy to the Bone Marrow

We recently developed a Janus kinase 2 (Jak2) small-molecule inhibitor called G6 and found that it inhibits Jak2-V617F-mediated pathologic cell growth in vitro, ex vivo, and in vivo. However, its ability to inhibit Jak2-V617F-mediated myeloproliferative neoplasia, with particular emphasis in the bon...

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Hlavní autoři: Kirabo, Annet, Park, Sung O, Majumder, Anurima, Gali, Meghanath, Reinhard, Mary K, Wamsley, Heather L, Zhao, Zhizhuang Joe, Cogle, Christopher R, Bisht, Kirpal S, Keserü, György M, Sayeski, Peter P
Médium: Artigo
Jazyk:Inglês
Vydáno: Neoplasia Press Inc. 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223609/
https://ncbi.nlm.nih.gov/pubmed/22131881
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