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UBR1 promotes protein kinase quality control and sensitizes cells to Hsp90 inhibition
UBR1 and UBR2 are N-recognin ubiquitin ligases that function in the N-end rule degradation pathway. In yeast, the UBR1 homologue also functions by N-end rule independent means to promote degradation of misfolded proteins generated by treatment of cells with geldanamycin, a small molecule inhibitor o...
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| Glavni autori: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3221935/ https://ncbi.nlm.nih.gov/pubmed/21983172 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexcr.2011.09.010 |
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