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Ubr1 and Ubr2 Function in a Quality Control Pathway for Degradation of Unfolded Cytosolic Proteins

Quality control systems facilitate polypeptide folding and degradation to maintain protein homeostasis. Molecular chaperones promote folding, whereas the ubiquitin/proteasome system mediates degradation. We show here that Saccharomyces cerevisiae Ubr1 and Ubr2 ubiquitin ligases promote degradation o...

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Main Authors: Nillegoda, Nadinath B., Theodoraki, Maria A., Mandal, Atin K., Mayo, Katie J., Ren, Hong Yu, Sultana, Rasheda, Wu, Kenneth, Johnson, Jill, Cyr, Douglas M., Caplan, Avrom J.
格式: Artigo
語言:Inglês
出版: The American Society for Cell Biology 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2893976/
https://ncbi.nlm.nih.gov/pubmed/20462952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-02-0098
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