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Production of ES1 Plasma Carboxylesterase Knockout Mice for Toxicity Studies
The LD(50) for soman is 10 to 20-fold higher for a mouse than a human. The difference in susceptibility is attributed to the presence of carboxylesterase in mouse, but not in human plasma. Our goal was to make a mouse lacking plasma carboxylesterase. We used homologous recombination to inactivate th...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2011
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3221923/ https://ncbi.nlm.nih.gov/pubmed/21875074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200237a |
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