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Production of ES1 Plasma Carboxylesterase Knockout Mice for Toxicity Studies

The LD(50) for soman is 10 to 20-fold higher for a mouse than a human. The difference in susceptibility is attributed to the presence of carboxylesterase in mouse, but not in human plasma. Our goal was to make a mouse lacking plasma carboxylesterase. We used homologous recombination to inactivate th...

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Bibliografiske detaljer
Main Authors: Duysen, Ellen G., Koentgen, Frank, Williams, Gareth R., Timperley, Christopher M., Schopfer, Lawrence M., Cerasoli, Douglas M., Lockridge, Oksana
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221923/
https://ncbi.nlm.nih.gov/pubmed/21875074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200237a
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