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Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran

Mouse blood contains four esterases that detoxify organophosphorus compounds: carboxylesterase, butyrylcholinesterase, acetylcholinesterase, and paraoxonase-1. In contrast human blood contains the latter three enzymes but not carboxylesterase. Organophosphorus compound toxicity is due to inhibition...

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Библиографические подробности
Главные авторы: Duysen, Ellen G., Cashman, John R., Schopfer, Lawrence M., Nachon, Florian, Masson, Patrick, Lockridge, Oksana
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3288885/
https://ncbi.nlm.nih.gov/pubmed/22209767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2011.12.006
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