REACTION OF CRESYL SALIGENIN PHOSPHATE, THE ORGANOPHOSPHORUS AGENT IMPLICATED IN THE AEROTOXIC SYNDROME, WITH HUMAN CHOLINESTERASES: MECHANISTIC STUDIES EMPLOYING KINETICS, MASS SPECTROMETRY AND X-RAY STRUCTURE ANALYSIS

The aerotoxic syndrome is assumed to be caused by exposure to tricresyl phosphate (TCP), an anti-wear additive in jet engine lubricants and hydraulic fluids. CBDP (2-(ortho-cresyl)-4H-1,2,3-benzodioxaphosphoran-2-one) is the toxic metabolite of tri-ortho-cresylphosphate, a component of TCP. Human bu...

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Detalhes bibliográficos
Main Authors: Carletti, Eugénie, Schopfer, Lawrence M., Colletier, Jacques-Philippe, Froment, Marie-Thérése, Nachon, Florian, Weik, Martin, Lockridge, Oksana, Masson, Patrick
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3118852/
https://ncbi.nlm.nih.gov/pubmed/21438623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx100447k
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