Predictive genetic testing for the identification of high-risk groups: a simulation study on the impact of predictive ability

BACKGROUND: Genetic risk models could potentially be useful in identifying high-risk groups for the prevention of complex diseases. We investigated the performance of this risk stratification strategy by examining epidemiological parameters that impact the predictive ability of risk models. METHODS:...

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Main Authors: Mihaescu, Raluca, Moonesinghe, Ramal, Khoury, Muin J, Janssens, A Cecile JW
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3221548/
https://ncbi.nlm.nih.gov/pubmed/21797996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gm267
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