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Discriminative accuracy of genomic profiling comparing multiplicative and additive risk models
Genetic prediction of common diseases is based on testing multiple genetic variants with weak effect sizes. Standard logistic regression and Cox Proportional Hazard models that assess the combined effect of multiple variants on disease risk assume multiplicative joint effects of the variants, but th...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3025793/ https://ncbi.nlm.nih.gov/pubmed/21081969 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2010.165 |
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