Life Span Extension via eIF4G Inhibition Is Mediated by Posttranscriptional Remodeling of Stress Response Gene Expression in C. elegans

Reducing protein synthesis slows growth and development but can increase adult life span. We demonstrate that knockdown of eukaryotic translation initiation factor 4G (eIF4G), which is downregulated during starvation and dauer state, results in differential translation of genes important for growth...

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Main Authors: Rogers, Aric N., Chen, Di, McColl, Gawain, Czerwieniec, Gregg, Felkey, Krysta, Gibson, Bradford W., Hubbard, Alan, Melov, Simon, Lithgow, Gordon J., Kapahi, Pankaj
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220185/
https://ncbi.nlm.nih.gov/pubmed/21723504
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.05.010
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