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C. elegans ortholog of mammalian Ku70 interacts with insulin-like signaling to modulate stress resistance and life span
The mammalian Ku heterodimer has important roles in DNA double strand break repair, telomere maintenance, cell cycle checkpoint-arrest, tumor suppression, and cellular stress resistance. To investigate the evolutionarily conserved functions of Ku, we knocked down expression by RNA interference (RNAi...
Bewaard in:
| Hoofdauteurs: | , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2005
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1400606/ https://ncbi.nlm.nih.gov/pubmed/16099946 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.04-2447fje |
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