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Two distinct catalytic strategies in the HDV ribozyme cleavage reaction()
The hepatitis delta virus (HDV) ribozyme and related RNAs are widely dispersed in nature. This RNA is a small nucleolytic ribozyme that self-cleaves to generate products with a 2’3’-cyclic phosphate and a free 5’-hydroxyl. Although small ribozymes are dependent on divalent metal ions under biologica...
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2011
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3220057/ https://ncbi.nlm.nih.gov/pubmed/22003985 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201157t |
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