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Two Divalent Metal Ions and Conformational Changes Play Roles in the Hammerhead Ribozyme Cleavage Reaction

The hammerhead ribozyme is a self-cleaving RNA broadly dispersed across all kingdoms of life. Although it was the first of the small, nucleolytic ribozymes discovered, the mechanism by which it catalyzes its reaction remains elusive. The nucleobase of G12 is well positioned to be a general base, but...

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Publicado en:Biochemistry
Autores principales: Mir, Aamir, Chen, Ji, Robinson, Kyle, Lendy, Emma, Goodman, Jaclyn, Neau, David, Golden, Barbara L.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710350/
https://ncbi.nlm.nih.gov/pubmed/26398724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00824
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