Synthesis of a fluorogenic cyclooctyne activated by Cu-free click chemistry

[Image: see text] Cyclooctyne-based probes that become fluorescent upon reaction with azides are important targets for real-time imaging of azide-labeled biomolecules. The concise synthesis of a coumarin-conjugated cyclooctyne, coumBARAC, that undergoes a 10-fold enhancement in fluorescence quantum...

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Detalles Bibliográficos
Main Authors: Jewett, John C., Bertozzi, Carolyn R.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219546/
https://ncbi.nlm.nih.gov/pubmed/22029411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol2025026
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https://ncbi.nlm.nih.gov/pmc/articles/PMC3219546/
https://ncbi.nlm.nih.gov/pubmed/22029411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol2025026