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A Hydrophilic Azacyclooctyne for Cu-Free Click Chemistry

[Image: see text] Biomolecules labeled with azides can be detected through Cu-free click chemistry with cyclooctyne probes, but their intrinsic hydrophobicity can compromise bioavailability. Here, we report the synthesis and evaluation of a novel azacyclooctyne, 6,7-dimethoxyazacyclooct-4-yne (DIMAC...

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Bibliografski detalji
Glavni autori: Sletten, Ellen M., Bertozzi, Carolyn R.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2008
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664610/
https://ncbi.nlm.nih.gov/pubmed/18549231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol801141k
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