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Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry
[Image: see text] The 1,3-dipolar cycloaddition of azides and activated alkynes has been used for site-selective labeling of biomolecules in vitro and in vivo. While copper catalysis has been widely employed to activate terminal alkynes for [3 + 2] cycloaddition, this method, often termed “click che...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Chemical Society
2008
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646667/ https://ncbi.nlm.nih.gov/pubmed/18680289 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja803086r |
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