Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes

Sickle cell disease (SCD) is a hematologic disorder caused by a missense mutation in the adult β-globin gene. Higher fetal hemoglobin (HbF) levels in red blood cells of SCD patients have been shown to improve morbidity and mortality. We previously found that nuclear receptors TR2 and TR4 repress exp...

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Autors principals: Campbell, Andrew D., Cui, Shuaiying, Shi, Lihong, Urbonya, Rebekah, Mathias, Andrea, Bradley, Kori, Bonsu, Kwaku O., Douglas, Rhonda R., Halford, Brittne, Schmidt, Lindsay, Harro, David, Giacherio, Donald, Tanimoto, Keiji, Tanabe, Osamu, Engel, James Douglas
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2011
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219144/
https://ncbi.nlm.nih.gov/pubmed/22042865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1104964108
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