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Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction
Enhanced fetal γ-globin synthesis alleviates symptoms of β-globinopathies such as sickle cell disease and β-thalassemia, but current γ-globin–inducing drugs offer limited beneficial effects. We show here that lysine-specific demethylase 1 (LSD1) inhibition by RNAi in human erythroid cells or by the...
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| Publicado no: | Nat Med |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5512162/ https://ncbi.nlm.nih.gov/pubmed/23416702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3101 |
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