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Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction

Enhanced fetal γ-globin synthesis alleviates symptoms of β-globinopathies such as sickle cell disease and β-thalassemia, but current γ-globin–inducing drugs offer limited beneficial effects. We show here that lysine-specific demethylase 1 (LSD1) inhibition by RNAi in human erythroid cells or by the...

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Publicat a:Nat Med
Autors principals: Shi, Lihong, Cui, Shuaiying, Engel, James D, Tanabe, Osamu
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512162/
https://ncbi.nlm.nih.gov/pubmed/23416702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3101
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