The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice

Inhibition of lysine-specific demethylase 1 (LSD1) has been shown to induce fetal hemoglobin (HbF) levels in cultured human erythroid cells in vitro. Here we report the in vivo effects of LSD1 inactivation by a selective and more potent inhibitor, RN-1, in a sickle cell disease (SCD) mouse model. Co...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Cui, Shuaiying, Lim, Kim-Chew, Shi, Lihong, Lee, Mary, Jearawiriyapaisarn, Natee, Myers, Greggory, Campbell, Andrew, Harro, David, Iwase, Shigeki, Trievel, Raymond C., Rivers, Angela, DeSimone, Joseph, Lavelle, Donald, Saunthararajah, Yogen, Engel, James Douglas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2015
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4504950/
https://ncbi.nlm.nih.gov/pubmed/26031919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-02-626259
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