The LSD1 inhibitor RN-1 recapitulates the fetal pattern of hemoglobin synthesis in baboons (P. anubis)

Increased fetal hemoglobin levels lessen the severity of symptoms and increase the lifespan of patients with sickle cell disease. Hydroxyurea, the only drug currently approved for the treatment of sickle cell disease, is not effective in a large proportion of patients and therefore new pharmacologic...

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Bibliografische gegevens
Gepubliceerd in:Haematologica
Hoofdauteurs: Rivers, Angela, Vaitkus, Kestis, Ibanez, Vinzon, Ruiz, Maria Armila, Jagadeeswaran, Ramasamy, Saunthararajah, Yogen, Cui, Shuaiying, Engel, James D., DeSimone, Joseph, Lavelle, Donald
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Ferrata Storti Foundation 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5013966/
https://ncbi.nlm.nih.gov/pubmed/26858356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2015.140749
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