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The spliceosome as an indicted conspirator in myeloid malignancies
Data from two recent studies of whole-exome sequencing of myelodysplastic syndrome (MDS) suggests spliceosome mutations have clinical relevance. Identifying the impact of these mutations on pre-mRNA splicing and MDS pathogenesis holds promise for targeted modulation of mRNA splicing in MDS.
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3218079/ https://ncbi.nlm.nih.gov/pubmed/22014568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.10.004 |
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