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The spliceosome as an indicted conspirator in myeloid malignancies

Data from two recent studies of whole-exome sequencing of myelodysplastic syndrome (MDS) suggests spliceosome mutations have clinical relevance. Identifying the impact of these mutations on pre-mRNA splicing and MDS pathogenesis holds promise for targeted modulation of mRNA splicing in MDS.

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書誌詳細
主要な著者: Abdel-Wahab, Omar, Levine, Ross
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218079/
https://ncbi.nlm.nih.gov/pubmed/22014568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.10.004
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