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Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia

Recent studies of the spectrum of somatic genetic alterations in acute myeloid leukemia (AML) have identified frequent somatic mutations in genes that encode proteins important in the epigenetic regulation of gene transcription. This includes proteins involved in the modification of DNA cytosine res...

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Autores principales: Abdel-Wahab, Omar, Levine, Ross L.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2013
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643757/
https://ncbi.nlm.nih.gov/pubmed/23640996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-01-451781
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