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Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia

Recent studies of the spectrum of somatic genetic alterations in acute myeloid leukemia (AML) have identified frequent somatic mutations in genes that encode proteins important in the epigenetic regulation of gene transcription. This includes proteins involved in the modification of DNA cytosine res...

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Bibliographic Details
Main Authors: Abdel-Wahab, Omar, Levine, Ross L.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3643757/
https://ncbi.nlm.nih.gov/pubmed/23640996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-01-451781
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