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The spliceosome as an indicted conspirator in myeloid malignancies

Data from two recent studies of whole-exome sequencing of myelodysplastic syndrome (MDS) suggests spliceosome mutations have clinical relevance. Identifying the impact of these mutations on pre-mRNA splicing and MDS pathogenesis holds promise for targeted modulation of mRNA splicing in MDS.

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Библиографические подробности
Главные авторы: Abdel-Wahab, Omar, Levine, Ross
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218079/
https://ncbi.nlm.nih.gov/pubmed/22014568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.10.004
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