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Evaluation of the Hydrolytic Activity of a Long-Acting Mutant Bacterial Cocaine in the Presence of Commonly Co-Administered Drugs
BACKGROUND: Cocaine toxicity is a prevalent problem in the Unites States for which there is currently no FDA-approved pharmacotherapy. We have developed a bacterial cocaine esterase (CocE) towards this indication. A thermostabilized mutant of CocE (DM-CocE) retains the hydrolytic activity of the wil...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3217061/ https://ncbi.nlm.nih.gov/pubmed/21775073 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drugalcdep.2011.06.018 |
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