A novel method for quantification of gemcitabine and its metabolites 2′,2′-difluorodeoxyuridine and gemcitabine triphosphate in tumour tissue by LC–MS/MS: comparison with (19)F NMR spectroscopy

PURPOSE: To develop a sensitive analytical method to quantify gemcitabine (2′,2′-difluorodeoxycytidine, dFdC) and its metabolites 2′,2′-difluorodeoxyuridine (dFdU) and 2′,2′-difluorodeoxycytidine-5′-triphosphate (dFdCTP) simultaneously from tumour tissue. METHODS: Pancreatic ductal adenocarcinoma tu...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Bapiro, Tashinga E., Richards, Frances M., Goldgraben, Mae A., Olive, Kenneth P., Madhu, Basetti, Frese, Kristopher K., Cook, Natalie, Jacobetz, Michael A., Smith, Donna-Michelle, Tuveson, David A., Griffiths, John R., Jodrell, Duncan I.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Springer-Verlag 2011
Konular:
Original Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215866/
https://ncbi.nlm.nih.gov/pubmed/21431415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-011-1613-0
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller