Mechanism of Action of NB2001 and NB2030, Novel Antibacterial Agents Activated by β-Lactamases

Two potent antibacterial agents designed to undergo enzyme-catalyzed therapeutic activation were evaluated for their mechanisms of action. The compounds, NB2001 and NB2030, contain a cephalosporin with a thienyl (NB2001) or a tetrazole (NB2030) ring at the C-7 position and are linked to the antibact...

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Detalhes bibliográficos
Main Authors: Stone, Geoffrey W., Zhang, Qin, Castillo, Rosario, Doppalapudi, V. Ramana, Bueno, Analia R., Lee, Jean Y., Li, Qing, Sergeeva, Maria, Khambatta, Gody, Georgopapadakou, Nafsika H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC321519/
https://ncbi.nlm.nih.gov/pubmed/14742198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.2.477-483.2004
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