NB2001, a Novel Antibacterial Agent with Broad-Spectrum Activity and Enhanced Potency against β-Lactamase-Producing Strains

Enzyme-catalyzed therapeutic activation (ECTA) is a novel prodrug strategy to overcome drug resistance resulting from enzyme overexpression. β-Lactamase overexpression is a common mechanism of bacterial resistance to β-lactam antibiotics. We present here the results for one of the β-lactamase ECTA c...

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Autors principals: Li, Qing, Lee, Jean Y., Castillo, Rosario, Hixon, Mark S., Pujol, Catherine, Doppalapudi, Venkata Ramana, Shepard, H. Michael, Wahl, Geoffrey M., Lobl, Thomas J., Chan, Ming Fai
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2002
Matèries:
Susceptibility
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC127132/
https://ncbi.nlm.nih.gov/pubmed/11959554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.46.5.1262-1268.2002
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