CD47–signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction

Monoclonal antibodies are among the most promising therapeutic agents for treating cancer. Therapeutic cancer antibodies bind to tumor cells, turning them into targets for immune-mediated destruction. We show here that this antibody-mediated killing of tumor cells is limited by a mechanism involving...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Zhao, Xi Wen, van Beek, Ellen M., Schornagel, Karin, Van der Maaden, Hans, Van Houdt, Michel, Otten, Marielle A., Finetti, Pascal, Van Egmond, Marjolein, Matozaki, Takashi, Kraal, Georg, Birnbaum, Daniel, van Elsas, Andrea, Kuijpers, Taco W., Bertucci, Francois, van den Berg, Timo K.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2011
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215076/
https://ncbi.nlm.nih.gov/pubmed/22042861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106550108
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