Functional characterization of the selective pan-allele anti-SIRPα antibody ADU-1805 that blocks the SIRPα–CD47 innate immune checkpoint

BACKGROUND: Accumulating preclinical data indicate that targeting the SIRPα/CD47 axis alone or in combination with existing targeted therapies or immune checkpoint inhibitors enhances tumor rejection. Although several CD47-targeting agents are currently in phase I clinical trials and demonstrate act...

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Vydáno v:J Immunother Cancer
Hlavní autoři: Voets, Erik, Paradé, Marc, Lutje Hulsik, David, Spijkers, Sanne, Janssen, Wout, Rens, Joost, Reinieren-Beeren, Inge, van den Tillaart, Gilbert, van Duijnhoven, Sander, Driessen, Lilian, Habraken, Maurice, van Zandvoort, Peter, Kreijtz, Joost, Vink, Paul, van Elsas, Andrea, van Eenennaam, Hans
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894304/
https://ncbi.nlm.nih.gov/pubmed/31801627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0772-0
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