CD47–signal regulatory protein-α (SIRPα) interactions form a barrier for antibody-mediated tumor cell destruction

Monoclonal antibodies are among the most promising therapeutic agents for treating cancer. Therapeutic cancer antibodies bind to tumor cells, turning them into targets for immune-mediated destruction. We show here that this antibody-mediated killing of tumor cells is limited by a mechanism involving...

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Hlavní autoři: Zhao, Xi Wen, van Beek, Ellen M., Schornagel, Karin, Van der Maaden, Hans, Van Houdt, Michel, Otten, Marielle A., Finetti, Pascal, Van Egmond, Marjolein, Matozaki, Takashi, Kraal, Georg, Birnbaum, Daniel, van Elsas, Andrea, Kuijpers, Taco W., Bertucci, Francois, van den Berg, Timo K.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2011
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215076/
https://ncbi.nlm.nih.gov/pubmed/22042861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106550108
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